Howard Hunter

The NMR Facility at York University

Experience

I began my career at McMaster University with Ph.D. studies focussing on both organic synthesis and the NMR spectroscopy of purine cyclophanes. My post-graduate work progressed to the study of peptide-protein interactions at the National Research Council in Montreal (NRC-BRI) with the assistance of a NSERC post-doctoral scholarship. I was also fortunate enough to be part of the lab of Professor Dr. William Power at the University of Waterloo to study gel phase or high resolution magic angle spinning (HRMAS) NMR as it applied to solid support peptide synthesis.

My knowledge of both high resolution NMR techniques and structural elucidation was substantially broadened as an applications spectroscopist at Bruker Spectrospin Canada Ltd. (now Bruker Biospin Ltd) and at Brantford Chemicals Inc.

Before joining York University, I was privileged to work as a Research Associate in the lab of Professor Dr. Hans Vogel at the University of Calgary where I studied the structure of peptides in micelle environments by NMR.

Currently, I supervise instruction and maintenance of the 300, 400 and 600 MHz NMR spectrometers at York University.

Publications

Howard N. Hunter, Weiguo Jing, David J. Schibli, Tony Trinh, In Yup Park, Sun Chang Kim and Hans J. Vogel (accepted Nov. 2004) �The Interactions of Antimicrobial Peptides Derived from Lysozyme with Model Membrane Systems� Biochimica et Biophysica Acta

Weiguo Jing, Howard N. Hunter, Hiroki Tanabe, Andre J. Oullette and Hans J. Vogel (accepted Sept. 2004) �Solution Structure of Cryptdin-4, a Mouse Paneth Cell a-Defensin� Biochemistry

Tao Yuan, Aldrin V. Gomes, Junor A. Barnes, Howard N. Hunter and Hans J. Vogel (2004) "Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I." Arch. Biochem. Biophys. 421(2): 192-206

Weiguo Jing, Howard N. Hunter, Jill Hagel and Hans J. Vogel (2003) "The structure of the antimicrobial peptide Ac-RRWWRF-NH2 bound to micelles and its interactions with phospholipid bilayers." J. Peptide Res. 61: 219-229.

Howard N. Hunter, D. Bruce Fulton, Tomas Ganz, and Hans J. Vogel (2002) "The solution structure of human hepcidin, a peptide-hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis." J. Biol. Chem. 277: 37597-37603.

David J. Schibli, Howard N. Hunter, Vladimir Aseyev, Timothy D. Starner, John M. Wiencek, Paul B. Mc (2002) "The Solution Structures of the Human -Defensins Lead to a Better Understanding of the Potent Bactericidal Activity of HBD3 against Staphylococcus aureus." J. Biol. Chem. 276: 8279-8289.

Michael J.T. Ditty, Howard N. Hunter, Rachel M.E. Mainville and William Power (2001) "NMR applications for solid-phase synthesis: Part I. Suppression of residual polymer signals in 1D 1H NMR spectroscopy of polymer-supported species." Magnetic Resonance in Chemistry 39: 241-248.

Dyanne Brewer, Howard Hunter and Gilles Lajoie (1998) "NMR studies of the antimicrobial salivary peptides histatin 3 and histatin 5 in aqueous and nonaqueous solutions." Biochemistry and Cell Biology. 76: 247-256.

Alfredo Capretta, Howard N. Hunter, Christopher S. Frampton and Russell A. Bell. (1992) �Synthesis, NMR Spectroscopy, and Crystal Structure of [9](N6,9)-6-Aminopurinophane." Can. J. Chem. 71: 96-106.

Russell A. Bell, R. Faggiani, Howard N. Hunter and Colin, J.L. Lock. (1992) �Synthesis, C-13 NMR and X-ray Crystal Structure of N6,N9-Octamethylene Purine Cyclophane.� Can. J. Chem. 70: 186-196.

Alex D. Bain, Donald W. Hughes and Howard N. Hunter (1988) �NMR of the Methylene Group: Artifacts in the Proton-Proton Decoupled Heteronuclear Two Dimensional Chemical Shift Correlation Experiment� Magnetic Resonance in Chemistry 26: 1058-1061.

Russell A. Bell and Howard N. Hunter (1987) �Synthesis and 1H NMR spectrum of N6',N9-octamethylenepurine cyclophane� Tetrahedron Letters 28: 147-150.